TEDMED and Alzheimer’s: Gregory Petsko, Reisa Sperling, and the next Al Gore
Apr12

TEDMED and Alzheimer’s: Gregory Petsko, Reisa Sperling, and the next Al Gore

Gregory Petsko knows why he came to TEDMED. "I'm looking for Al Gore," he told me flat-out over lunch. Folks who know Petskoknow the former Brandeis University biochemistry department chair isn't one to mince words. And he's nailed the reason why an academic might want to look outside traditional conferences and soak up some of the TEDMED aura. He's looking for a charismatic champion to take up a biomedical cause: in Petsko's case, it's support for research in Alzheimer's disease. Petsko and Reisa Sperling, director of the Center for Alzheimer's Research and Treatment at Brigham and Women’s Hospital, talked about Alzheimer's at TEDMED on Wednesday. Both talks were cast as calls to action. Just consider the introduction Petsko got from TEDMED chair and Priceline.com founder Jay S. Walker: "This is a man who hears a bomb ticking." Alzheimer's statistics are sobering and Petsko used them to dramatic effect. People who will reach 80 by the year 2050 have a 1 in 3 chance of developing the disease if nothing is done, he told the audience. "And yet I hear no clamor," he said. "I hear no sense of urgency." Petsko shared some not-yet-published work with TEDMED's audience. His team is looking at a less-trod path of Alzheimer's biology-- the role protein sorting defects might play in the development of the disease. Their focus is on a protein complex called the retromer, which Petsko likened to a truck driver, because its job is to sort and send proteins either to the golgi--the cell's recycling center, or to the lysosome for snipping. For Alzheimer's, the thought is that improper sorting can make the difference between normalcy and an accumulation of amyloid-beta, the protein thought to be a key player in developing the disease. Petsko told me that his collaborator, Scott Small of Columbia University Medical School, discovered that retromer played a role in Alzheimer's (Neuron, DOI: 10.1016/j.neuron.2006.09.001).   Petsko's team has developed small molecules that increase the level of active retromer complex in the cell. So far, their agents have been evaluated in cultured cells. Tests in mice are ongoing. It's important for the Alzheimer's field to look beyond amyloid-beta, says Kevin Sweeney, a TEDMED attendee who teaches at the University of California, Berkeley's Haas School of Business and is part of the Rosenberg Alzheimer's Project, a nascent organization that supports alternative avenues in Alzheimer's research. "For a while, at least, the Alzheimer's space looks like so many of the [clinical] trials have pursued a relatively narrow range of theories," he says. Even though those theories aren't fully played out, "we still think it's useful to start looking for other strands,"...

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Amusing News Aliquots
Oct13

Amusing News Aliquots

Silly samplings from this week's science news, compiled by Jyllian Kemsley and Lauren Wolf. Which ink should you use in your lab notebook? This guy has thought a lot about it. [ColinPurrington.com] Researchers cure mice of peanut allergies. Speedy Gonzales raids Reese’s plant. ¡Arriba! ¡Arriba! [Northwestern] Alzheimer’s could be contagious, say scientists who injected brain material from patients into mice. Now if we could just get Alzheimer’s patients to stop injecting others with their brain bits. [Discovery News] The Big Picture: Nikon Small World Photomicrography Competition. Neurons, microchips, and water fleas--oh my! [Boston.com] LEGOs + cell phone = new sensor for watching cells grow in real time. [Gizmodo] Want to slow down an already slow commute? Ban the single-driver hybrid vehicles from the carpool lane, transportation engineers say. [Berkeley]...

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