Chemical safety tidbits and papers, from OPRD

A tweet from Chemjobber that Organic Process Research & Development editor Trevor Laird is retiring at the end of the year made me realize that I forgot to highlight OPRD’s annual “Safety of Chemical Processes” section at the end of last year. Making up for the omission:

Laird’s editorial: “There is a long way to go to educate and train to a high standard all chemists working in laboratories and chemical plants and to minimize the number of these incidents, which lead to damage to buildings and loss of profits, as well as loss of life. Companies always measure the cost of doing something (e.g., training) but never measure the cost of not doing something; there is a cost of not training staff, however, just as there is a cost associated with not complying with regulations (e.g., FDA regulations).”

Safety Notables: Information from the Literature, including notes about Togni’s reagent, dimethylsulfoxide, hydroxylamine, peroxides, dimethyldioxirane, nitro-explosives, and safer reagents for a number of reactions

Hydrazine and Aqueous Hydrazine Solutions: Evaluating Safety in Chemical Processes, from Lilly Research Laboratories

Safer Preparation of m-CPBA/DMF Solution in Pilot Plant, from Suzhou Novartis Pharma Technology

Process Safety Evaluation To Identify the Inherent Hazards of a Highly Exothermic Ritter Reaction Using Adiabatic and Isothermal Calorimeters, from Mylan Laboratories

Safe Scale-Up of a Hydrazine Condensation by the Addition of a Base, from AbbVie

Merck’s Reaction Review Policy: An Exercise in Process Safety, from Merck

Author: Jyllian Kemsley

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