Organic Process Research and Development editor Trevor Laird, founder of Scientific Update, recently penned an editorial on “Safety Culture in Industry and Academia”. I’ll highlight one particular paragraph:
Unfortunately, many companies and most universities are still not using the literature to find out more safety information (and not just MSDSs); for example, Bretherick’s Handbook of Reactive Chemical Hazards is a superb resource to access the literature with respect to safe handling of chemicals, in particular on the issues with scaling up. In the organic synthesis literature, I have seen so many unsafe procedures using perchloric acid/perchlorates and azides/hydrazoic acid, for example, that it is surprising there have not been more explosions in university laboratories. Yet a look through recent issues of Organic Process Research & Development (OPRD) will garner several fine articles which describe exactly the dangers of azides, how to overcome those dangers and to scale up the processes, as well as a book review on this topic.
There’s clearly a challenge here for researchers to figure out what’s a safe procedure and what isn’t. Just because a journal published something doesn’t mean it’s been vetted for safety. Is there a good way to teach students to be appropriately skeptical of literature procedures? Also, aside from using Bretherick’s and OPRD, are there other good resources for people trying to evaluate a procedure for safety?