The Tail’s The Thing – Alkylamine Ethers and Zafgen’s ZGN-433
Jul13

The Tail’s The Thing – Alkylamine Ethers and Zafgen’s ZGN-433

While posting about the Zafgen obesity drug candidate yesterday, I was staring at the Markush structure we’d drawn for ZGN-433 when Carmen Drahl sent over a 2008 volume of the World Health Organization International Nonproprietary Names (INN) list, a collection of proposed or recommended non-proprietary names and structures for currently-marketed drugs or drug candidates in clinical trials. I glanced down the list to find beloranib,...

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Zafgen’s Obesity Drug Shows Promise, Gets Funding
Jul12

Zafgen’s Obesity Drug Shows Promise, Gets Funding

Zafgen, whose science has been the subject of much speculation on the Haystack (see earlier posts), has again found favor with investors, despite a tough climate for obesity drug developers. Last week, the company scored $33 million in Series C venture financing to move its drug ZGN-433 (beloranib hemioxalate) into Phase II trials (We found beloranib’s structure in WHO’s drug information Vol. 22, No. 4). This new cash...

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Zafgen’s ZGN-433 shows promise for obesity- so what’s it look like?
Jan05

Zafgen’s ZGN-433 shows promise for obesity- so what’s it look like?

Just in time to coincide with January’s massive uptick in gym-going, Cambridge, MA startup Zafgen has announced good news about its experimental weight-loss drug for severe obesity. The molecule, ZGN-433, helped a small group of severely obese women (with body mass index of 32-45) lose weight- more so than a placebo. Weight losses varied from person to person, but the midpoints of the range of weight loss results were...

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Zafgen Unveils Target of its Experimental Obesity Drugs: Methionine Aminopeptidase 2- UPDATED
Jun26

Zafgen Unveils Target of its Experimental Obesity Drugs: Methionine Aminopeptidase 2- UPDATED

When I first wrote about obesity drug development back in 2009 I talked with Zafgen, Inc., a biopharmaceutical company working to develop its own obesity medications. At the time, the company was keeping the molecular specifics of what they were doing pretty close to the vest. We knew from Zafgen’s website that the company was not targeting the brain like many other obesity drugs do, including lorcaserin, Qnexa, and Contrave,...

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Celgene & Avila Forge Permanent Ties

Today brought a spate of M&A activity in the biotech space, with Amgen unveiling a $1.2 billion bid for Micromet, and Celgene agreeing to pay up to $925 million for Avila Therapeutics. Both deals brought the acquirer a drug in development to treat blood cancers, while also adding a platform technology to their research engines. Being all about the chemistry, The Haystack is particularly interested in the Celgene/Avila deal, which...

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