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  1. Virgil
    Jan 27 - 10:49 am

    Interesting. Another biotech with covalents in their pipeline is complexa ( Their molecules are mostly electrophilic nitro-alkenes that adduct thiols in targets such as PPARs, NFKB etc. Depending on exactly what amino acid is being adducted, and how the molecules select a motif within a protein, specificity is still a question – after all, something like 95% of proteins have at least one cysteine residue.

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