arrow5 Comments
  1. Deborah
    Aug 30 - 1:47 pm

    I thought you might be interested in this MD Anderson Cancer Center video on new research on lung cancer: It’s particularly important to patients who cannot have surgery for an early stage lung cancer – they can now benefit from a new radiation therapy technology called stereotactic radiation therapy (STARS).

  2. Greg Pawelski
    Sep 01 - 1:06 am

    With the lastest press release from Pfizer about their new drug Xalkori, the queston of whether to consider spending $3,000 or more for a cell-based functional profiling test gets more interesting. The drug will cost $9,600 per patient per month and the gene test for it will cost $1,500 per patient. A biotech executive states the real cost of the drug is $9,600 plus 25 ALK tests, because that’s how many patients will need to be screened for one to actually get Xalkori.

    There are lots of things which determine if drugs work, beyond the existence of a given target (like ALK). Does the drug even get into the cancer cell? Does it get pumped out of the cell? Does the cell have ways of escaping drug effects? Can cells repair damage caused by the drug? Do combinations of drugs work in ways which can’t be predicted on the basis of static gene expression patterns?

    Tumor biology is a lot more complex than we’d like it to be. Cancer is more complex than its gene signature. Many common forms of cancer present as a host of mutated cells, each with a host of mutations. And they’re genetically unstable, constantly changing. That’s why so many cancers relapse after initially successful treatment. You kill off the tumor cells that can be killed off, but that may just give the ones that are left a free reign.

    The idea of searching for clinical responders by testing for a single gene mutation seems like a nice theoretical idea, but you may have to test for dozens of protein expressions that may be involved in determining sensitivity/resistance to a given drug. Because if you miss just one, that might be the one which continues cancer growth. And at $1,500 a pop, that’s a lot of dough, on top of the inflated price of the single drug!

    The key to understanding the genome is understanding how cells work. The ultimate driver is “functional” pre-testing (is the cell being killed regardless of the mechanism) as opposed to “target” pre-testing (does the cell express a particular target that the drug is supposed to be attacking). While a “target” test tells you whether or not to give “one” drug, a “functional” pre-test can find other compounds and combinations and can recommend them, all from the one test.

  3. nalinee agarwal
    Sep 17 - 9:44 am

    how can we get this drug in the Indian Market

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