Researchers know that GPCR’s span cell membranes, snaking back and forth across them a total of seven times. But sometimes it’s the subtle details of structure that are important for understanding how they work. Protein structures are published quite frequently, but on the rare occasion when a GPCR structure is solved, it’s a big deal. Today Ph.D. biochemist Mary Canady (@Comprendia), founder of bioscience consulting group Comprendia, tweeted this list of the GPCR structures that have been determined so far, which she obtained via Peter Nollert at Emerald BioStructures (@reducentropy). I wish the list were longer.
Bonus pre-Friday happy hour info: Canady is tweeting from the Allosteric Modulator Drug Discovery Congress, where she is picking up tidbits galore about GPCR’s. If you want to know more about allosteric modulation (anything from what it is to what kinds of drugs are in the pipeline), read my backgrounder from last year. It mentions the Rolling Stones, valium, and alcohol. What’s not to like?
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