NC legislators aim to clean up “bath salt” omission
Feb19

NC legislators aim to clean up “bath salt” omission

Earlier this week, I wrote about on the comprehensive chemistry text in two North Carolina state bills – H12/S9 and H13/S7 – to criminalize distribution, sales, and possession of compounds present in a variety of legal-high, designer drug products. One bill specifically addressed compounds present in synthetic marijuana compounds whose extensive list included those eponymous JWH compounds synthesized in the laboratory of Clemson University Professor Emeritus, John W. Huffman (featured here). The other bill addressed mephedrone (4-methylmethcathinone; 4-MMC) and other structural analogs of this amphetamine and cathinone derivative. However, I noted my surprise at the time at the omission of a compound more commonly associated with so-called bath salt products: MDPV, or methylenedioxypyrovalerone. My neuroscience blogging colleague DrugMonkey also remarked to me of his surprise since most other states deal with MDPV in the same legislation with mephedrone/4-MMC because of their structural similarity. But on Thursday I was tipped off by WRAL-TV Capitol News Bureau Director, Laura Leslie, that a separate bill, Senate Bill 77 (S77), was just filed by State Senator Stan Bingham (R, NC-33) that specifically proposes to criminalize MDPV. Unlike the earlier bills, this one does not appear to currently have a House counterpart so I’m unclear as to how this will be dealt with in the other body. The bill now goes to judiciary committee. The “bath salt” phenomenon began to grab US media attention in late 2010 as state poison control centers began to receive reports of emergency room visits by people using legal high products that were not synthetic marijuana. According to Mark Ryan, Louisiana Poison Control Center Director, these products are sold under such names as Cloud 9, Ivory Wave, Ocean, Charge Plus, White Lightning, Scarface, Hurricane Charlie, Red Dove and White Dove. These currently skirt drug laws by claiming “not for human consumption” or as bath salts, plant food, or insect repellent. As with synthetic marijuana products, an advantage of these drugs is that they can’t be detected by the most common urinary drug screens such as the SAMHSA 5 (Quest Diagnostics example here). These products providing those on probation or otherwise subject to mandatory drug testing with a psychoactive alternative to amphetamines or Ecstasy. TIME Healthland writer, Maia Szalavitz, remarked to me recently of her concern about kids hearing stories about “bath salts” and then trying to smoke Mom’s Calgon. Not a good idea. Trying to do so may indeed, “take me away.” From a neuropharmacology perspective, even less data are available on MDPV than for mephedrone. MDPV is the 3,4-methylenedioxy derivative of pyrovalerone, a compound first synthesized by Heffe in 1964 and investigated in the 1970s in Europe as...

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Strong chemistry in NC bills banning legal highs
Feb12

Strong chemistry in NC bills banning legal highs

On Wednesday, two bills passed unanimously in the North Carolina State Senate that would outlaw synthetic cannabimimetics and mephedrone. These compounds are currently sold as Spice incense (e.g., K2, Black Mamba) or “bath salts” (e.g., Ivory Wave), respectively. (Many thanks to WRAL-TV Capitol Bureau Chief Laura Leslie and fellow blogger DrugMonkey for alerting me to these bills via Twitter.). Legislatively, similar bills have been passed and laws enacted in states and municipalities around the US while a proposed scheduling rule by the federal drug agency, the DEA, languishes in an administrative and legal morass. The synthetic marijuana bill, House Bill 12 (Senate 9) and the mephedrone bill, House Bill 13 (Senate 7), were originally both put forth in the NC House by co-sponsors led by Representative George Cleveland (R, NC-14) of Jacksonville, North Carolina, home to the US Marine base Camp Lejeune. Cleveland himself is a retired, 25-year US Marine. The US military has been far ahead of other state and federal agencies in prohibiting use of these chemicals and associated products. But for readers of this blog, the part of the NC bills that most impressed me was the exhaustive and near-encyclopedia listing of chemicals to be outlawed under the bills. For example, while the DEA has proposed to only regulate five compounds (and implied prohibition of structural analogs), take a gander at this list: The following controlled substances are included in this schedule: (6) Synthetic cannabinoids. – Any material, compound, mixture, or preparation that contains any quantity of the following substances, their salts, isomers (whether optical, positional, or geometric), homologues, and salts of isomers and homologues, unless specifically excepted, whenever the existence of these salts, isomers, homologues, and salts of isomers and homologues is possible within the specific chemical designation: a. Naphthoylindoles. Any compound containing a 3‑(1‑naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1‑(N‑methyl‑2‑piperidinyl)methyl, or 2‑(4‑morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any extent. Some trade or other names: JWH‑015, JWH‑018, JWH‑019, JWH‑073, JWH‑081, JWH‑122, JWH‑200, JWH‑210, JWH‑398, AM‑2201, WIN 55‑212. b. Naphthylmethylindoles. Any compound containing a 1H‑indol‑3‑yl‑(1‑naphthyl)methane structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1‑(N‑methyl‑2‑piperidinyl)methyl, or 2‑(4‑morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any extent. c. Naphthoylpyrroles. Any compound containing a 3‑(1‑naphthoyl)pyrrole structure with substitution at the nitrogen atom of the pyrrole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl,...

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