The Case Of The Malodorous Metabolite
Apr06

The Case Of The Malodorous Metabolite

Over where I also write at Forbes.com, Matthew Herper, Senior Editor for Pharma and Healthcare, reported on GlaxoSmithKline’s NEJM clinical trial of darapladib in coronary artery disease. The drug had been developed as a small molecule, orally-formulated, subnanomolar inhibitor of lipoprotein-associated phospholipase A2. Lp-PLA2 is associated with apolipoprotein B-containing lipoproteins, such as LDL and non-HDL particles, and...

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Acetyl Fentanyl: Dangerous, Poorly-Named Street Drug
Aug30

Acetyl Fentanyl: Dangerous, Poorly-Named Street Drug

The U.S. Centers for Disease Control and Prevention has released a summary on a cluster of 14 deaths in Rhode Island earlier this year attributed to “acetyl fentanyl,” an analog of the potent, short-lived opioid used in pain management and outpatient anesthesia. The report, “Notes from the Field: Acetyl Fentanyl Overdose Fatalities — Rhode Island, March–May 2013,” appears in the August 30, 2013 issue of...

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Making People Hate Chemistry on Halloween
Oct31

Making People Hate Chemistry on Halloween

Thanks to a tip from ChemBark et al., here is the most “insanely irresponsible” promotion of hazardous chemistry demos that I’ve seen. Written by Gizmodo Contributing Editor Eric Limer, the post draws from books by author William Gurstelle (Backyard Ballistics, Absinthe & Flamethrowers). On one hand, Gurstelle has done much to promote scientific curiosity among the public. That’s a good thing. Plus,...

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Legislation to protect men from PDE5 inhibitors
Mar04

Legislation to protect men from PDE5 inhibitors

I’ve been rather quiet here as of late, Dear Reader. Between my new day job and trying to finish my book chapter on natural toxins while fighting an overall bout of writer’s block, these pages have been devoid of pixels. But I couldn’t resist posting this news that came across my screen from various sources: State Senator Nina Turner (D-Cleveland) announced legislation today that would protect men in Ohio from the...

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Four Loko for Locos

Well, that was fast. After a year-long investigation of pre-made, highly-caffeinated alcoholic beverages, the US FDA today warned four companies to go decaf. The U.S. Food and Drug Administration today warned four companies that the caffeine added to their malt alcoholic beverages is an “unsafe food additive” and said that further action, including seizure of their products, is possible under federal law. The companies receiving...

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