arrow9 Comments
  1. Scicurious
    May 18 - 8:08 AM

    Walkin’ around inhibiting liver enzymes?!?! This sounds like a completely horrible idea. I am sad that the makers of my beloved caffeinated gum are selling this.

    Also, it seems like a bit of a round about way to de-caffeinate, having to wait several days to increase liver enzyme production, if that even has the desired effect…why not sell a competitive adenosine 1A agonist? I don’t think it’d be 100 percent effective, but it’s be better.

  2. Brandon the Engineer
    May 18 - 8:55 AM

    This sounds like all types of bad. Just as well start hooking up buttons to our bodies to turn us on, off, overclocked, and sleep. Drugs are turning us into living computers.

  3. David Bradley
    May 18 - 8:55 AM

    I was just about to post a comment to say I’d had some info from the manufacturers when I spotted your flattering footnote, you meke me blush…

  4. stan linnet
    May 19 - 10:09 AM

    Effects of Rutaecarpine on the Metabolism and Urinary Excretion of
    Caffeine in Rats
    Keumhan Noh
    , Young Min Seo
    , Sang Kyu Lee
    , Sudeep R. Bista
    , Mi Jeong Kang
    , Yurngdong Jahng
    Eunyoung Kim2
    , Wonku Kang
    , and Tae Cheon Jeong
    College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea and
    College of Pharmacy, Chungnam National
    University, Daejeon 305-764, Korea
    (Received May 14, 2010/Revised August 2, 2010/Accepted September 5, 2010)
    Although rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been reported to reduce the systemic exposure of caffeine, the mechanism of this
    phenomenon is unclear. We investigated the microsomal enzyme activity using hepatic S-9
    fraction and the plasma concentration-time profiles and urinary excretion of caffeine and its
    major metabolites after an oral administration of caffeine in the presence and absence of
    rutaecarpine in rats. Following oral administration of 80 mg/kg rutaecarpine for three consecutive days, caffeine (20 mg/kg) was given orally. Plasma and urine were collected serially for
    up to 24 h and the plasma and urine concentrations of caffeine and its metabolites were measured, and compared with those in control rats. The areas under the curve of both caffeine and
    its three major metabolites (paraxanthine, theophylline, and theobromine) were significantly
    reduced by rutaecarpine, indicating that caffeine was rapidly converted into the desmethylated metabolites, and that those were also quickly transformed into further metabolites via
    the hydroxyl metabolites due to the remarkable induction of CYP1A2 and 2E1. The significant
    induction of ethoxyresorufin O-deethylase, pentoxyresorufin O-depentylase, and p-nitrophenol
    hydroxylase strongly supported the decrease in caffeine and its major metabolites in plasma,
    as well as in urine. These results clearly suggest that rutaecarpine increases the metabolism
    of caffeine, theophylline, theobromine, and paraxanthine by inducing CYP1A2 and CYP2E1 in
    Key words: Caffeine, Metabolites, Rutaecarpine, Cytochrome P450, Rat
    here is an independent source confirming rutaecarpine is a cyp1a2 inducer.(which is what david bradley reported)
    the studies we did with university of pacific showed the half life of rutaecarpine was around 4 hours.
    as a skeptical pharmacist myself i am continually amazed with rutaesomn positive efficacy. it really works.
    safety concern with fruit derived ingredient? people taking other medications should not take rutaesomn without first consulting their health care provider.

    • worlebird
      Aug 16 - 8:43 PM

      Re: the study posted by stan linnet
      Doesn’t the study you posted say exactly what David is saying in this blog? The rats were not fed caffeine all day, and then fed some rutaecarpine and then tested. Rather, to quote your post, “Following oral administration of 80 mg/kg rutaecarpine for three consecutive days, caffeine (20 mg/kg) was given orally.” So the rats were fed rutaecarpine for 3 days first, then given caffeine and tested. That’s exactly the kind of effect David is writing that one might expect. It is NOT, however, the effect that the pills are being advertised with. The study emphatically does NOT demonstrate efficacy for the action being advertised, and the actual efficacy demonstrated by the study is probably undesirable to most consumers. In summary, it is likely that the effects being experienced by consumers who give testimonials (“It really works!”) are placebo effects, something that can (and should) be tested.

  5. stan linnet
    May 19 - 10:35 AM

    terra sigillata and david bradley are more than welcome to request samples of rutaesomn from our website and try our product. i love talking to brilliant scientists about our product (but still a little intimidated).still enjoying the wow moment when they find out that rutaesomn really works.

  6. Jon
    May 30 - 11:36 AM

    Gotta love ThinkGeek. I’ve bought numerous Christmas and birthday gifts for other people. Every year they get more fun and useless toys for my desk and others.

  7. Julie
    Jun 08 - 6:06 PM

    I just ordered a father’s day gift from that web site. Thanks

  8. fitness guy
    Sep 26 - 9:54 PM

    Funny how we see things that are supposed to fix a problem can actually do the opposite when looked at in real life situations.

    I am very sensitive to caffeine and do not drink any after noon at all or it does in fact keep me up. I would have in retrospect tried this and gotten myself in big sleep problems

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