Category → I can't believe my life happens to me
My apologies to regular readers and my colleagues at C&EN for my month-long silence at the blog. I saw cobwebs on my laptop screen when I opened the back end this morning. Part of my hiatus came from complications of an infected molar extraction and my inability to concentrate. I’ve also been trying to take short Internet holidays over the last two months because all of the political nonsense in my state is negatively affecting my mental health.
But the tooth canyon is about 50% healed and our state legislature has finished, for now, shifting progressive North Carolina toward its pre-Research Triangle Park level of ignorance, racism, and poverty.
During this month, I came across an excellent post on the Scientific American Guest Blog by Atlanta-based science journalist, Kathleen Raven. In “Ada Yonath and the Female Question,” Raven discusses her experience at this year’s Lindau Nobel Laureate meeting — dedicated to chemistry — and her reflections on hearing and attempting to interview the 2009 Nobelist in chemistry, Dr. Ada Yonath.
Yonath, a structural chemist recognized for her extensive work in showing how the ribosome catalyzes protein synthesis, has generally not made much of the fact that she’s only the fourth woman to receive the Nobel Prize in Chemistry, and the first since Dorothy Hodgkin in 1964.
As I did back in 2009 when interviewing Yonath at the North Carolina Biotechnology Center, Raven debates whether focusing on Yonath as a female scientist is a good thing for the cause of women scientists. Should we focus only on the accomplishments? Or should we focus on her accomplishments in the context of the distinct barriers often facing women scientists?
I’m equally torn, particularly since my 20-year laboratory career was advanced by a group that consistently ranged from 75% to 100% women. I never specifically recruited women to my laboratory but it seems that they might have self-selected for reasons not known to me. My activism in diversity in science extends back to my pharmacy faculty days at the University of Colorado where I assisted in selecting minority scholarship recipients for a generous program we had from the Skaggs Family Foundation.
The goings-on in North Carolina politics is not germane to this scientific discussion. We can speak all we want about our modern society being post-racial and having more women leaders than ever. But voter laws that disproportionately disenfranchise African-Americans and legislation that severely compromises women’s reproductive health tells me that we still need to pay attention to the influence of racial and gender attitudes.
Heck, even our Governor Pat McCrory showed his true colors yesterday while protestors, primarily women, were holding a vigil marking his signature of restrictive abortion legislation: He stepped out of the governor’s mansion to give protestors a plate of cookies and quickly returned behind the iron gates without any substantive engagement.
I’d be interested to hear from CENtral Science and C&EN readers after reading my own interview with Ada Yonath. Should we still be making an issue of advances in race, gender, and sexual orientation in chemistry?
I think yes, and it’s never been more important.
This post appeared originally on 14 December 2009 at the ScienceBlogs.com home of Terra Sigillata.
Last week in Stockholm (and Oslo), the 2009 Nobel Prize winners were gloriously hosted while giving their lectures and receiving their medals and diplomas. In Chemistry this year, the Nobel was shared by Venkatraman Ramakrishnan, Thomas A Steitz, and Ada E Yonath for their studies on the structure and function of the ribosome, a remarkable nucleoprotein complex that catalyzes the rapid, coordinated formation of peptide bonds as instructed by messenger RNA. My post on the day of the announcement in October was designed to counter the inevitable (and now realized) criticisms that the prize was not for “real” chemistry.
Only ten days later, we in the NC Research Triangle area were very fortunate to host Dr Yonath at the North Carolina Biotechnology Center for the Symposium on RNA Biology VIII, sponsored by The RNA Society of North Carolina.
Among the many noteworthy speakers was Dr Greg Hannon from Cold Spring Harbor Laboratory, a scientist who some feel was overlooked for the 2006 Nobel Prize in Medicine or Physiology, one where Andrew Fire and Craig Mello were recognized for RNA interference and gene silencing.
NC Biotech’s Senior Director of Corporate Communication, Robin Deacle, kindly invited me to an audience with Dr Yonath and two science reporters following Dr Yonath’s lecture. As you might suspect, I was quite honored to visit for awhile with the woman who defied the naysayers and successfully crystallized a bacterial ribosome, then used X-ray crystallography to determine its structure below three angstroms resolution. The fact that she also used natural product antibiotics to stabilize ribosomal structure added to my magnitude of admiration.
Continue reading →
As I alluded to earlier on this index page, I was fortunate to score the cover story the January 9th issue of the Research Triangle’s alternative weekly paper, INDY Week. Therein, I told the story of Robert J. Lefkowitz, MD, the biochemist and cardiologist who shared the Nobel Prize in Chemistry 2012 with his former cardiology fellow, Brian K. Kobilka, MD, of Stanford University.
In this first edition of pixels that didn’t make it to the final article, I want to follow on the moments after I took this photo after interviewing Bob for the article. He was kind enough to bring in his original Nobel medal and diploma for me to see and photograph (he’s currently having a replica made of the medal so that he doesn’t have to carry around the real one.).
I was fortunate to be able to tell the story of Duke University biochemist and cardiologist Dr. Robert J. Lefkowitz in the 9 January 2013 issue of the Research Triangle’s award-winning alt-weekly, INDY Week.
Even with editor Lisa Sorg graciously offering 3,000+ words for the story on one of the 2012 Nobel laureates in chemistry, some terrific bits of my interviews with Bob and major players in his story didn’t make it into the final version.
Over the next few days, I’ll post some of these gems. This page will index the running list of those posts.
The Nobel’s Great, But Take a Look at This! – Lefkowitz reveals where Duke men’s basketball sits in his list of priorities
The NCCU Eagles RISE program is a NIH/NIGMS research education program for which I serve as principal investigator at North Carolina Central University in Durham. When I moved to the Research Triangle area, I had the opportunity to work as a pharmacologist with the late Dr. Monroe Wall and Dr. Mansukh Wani, scientists who with colleagues discovered the anticancer compounds, taxol and camptothecin.
I first came to know of Dr. Wani while I was a graduate student in 1987 while attending a DNA topoisomerase chemotherapy conference at NYU in Manhattan. To be honest, I was too nervous to even introduce myself to this legend of natural products chemistry. Almost 25 years later, I am now blessed to call him a family friend. One of the other joys I have is sharing the now 86-year-old Dr. Wani and his story with my students. Here’s a recap of our visit with him as posted on our NCCU Eagles RISE blog:
Many thanks to all of you, Dear Readers and C&EN editors and staff, I have been writing here for one year.
Last August 24th, we moved the Terra Sigillata blog here after its purgatory in indie WordPress land following four years at ScienceBlogs. The announcement came at the a ACS Medicinal Chemistry Lunch-and-Learn session on pharmaceutical and chemistry blogging led by Carmen Drahl at last year’s Boston meeting. the setting seemed appropriate for the launch because I was on the panel with two of my own blogging idols, Derek Lowe of In the Pipeline and Ed Silverman of Pharmalot.
In my inaugural post here last year, The Right Chemistry, I expressed my sincere thanks to Carmen and C&EN Online Editor Rachel Pepling for taking in this wayward blogger. Although I am technically a biologist, I have appreciated since my undergrad days that chemistry was central to moving forward in this field. As a pharmacologist whose previous pseudonym acknowledged Journal of Biological Chemistry founder, John Jacob Abel, I have always appreciated that my field would not be here without the efforts of synthetic chemists.
So, I hope that in the past year I have brought you a biologist’s view of – and reverence for – the discipline of chemistry.
Yes, I’ve tagged this post in my category, “I Can’t Believe My Life Happens to Me.”
During the week of May 30th, I had the pleasure of participating in the Santa Fe Science Writing Workshop, a 15-year labor of love run by New Mexico-based science writers, Sandra Blakeslee and George Johnson. This year, about 50 “students” were in attendance, ranging from professional writers like Dr. Wolf at C&EN and Newscripts above to freelancers, public information officers, and other academics like me who are working on improving our skills to communicate science to non-technical audiences.
Welcome to the new home of Terra Sigillata, a blog about the pharmacology and chemistry of natural product drugs and dietary supplements, issues of under-represented groups in the STEMM disciplines, science and medical journalism, and the influence of science in popular culture.
Tomorrow, I’ll tell you more about the blog itself but I wanted to launch with a personal narrative of how I got here.
Hello, my name is David…and I’m a science blogger
I’m your humble blogger, David Kroll, a molecular cancer pharmacologist and professor in the pharmaceutical sciences at a state university in the southern US. If you are an old-time reader of Terra Sig, you’ll know me as Abel Pharmboy, the pseudonym I selected to honor John Jacob Abel. Abel is considered the American father of pharmacology, having founded the first US departments of pharmacology (at Michigan and Johns Hopkins) as well as the American Society for Pharmacology and Experimental Therapeutics (ASPET), the Journal of Biological Chemistry, and the Journal of Pharmacology and Experimental Therapeutics.
But feel free to call me Abel. It’s a habit for many and folks in my daily life still know me as Abel.
And if you followed me on Twitter @abelpharmboy, just go ahead and follow me now @davidkroll.
After a fantastic four year run at ScienceBlogs.com, Terra Sig has spent a month in indie blog limbo while I searched for the right home for us. Some of my very dear friends are now at the wonderful new blog collective, Scientopia. I do hope to have a presence there in an educational capacity.
But where to bring little ol’ Abel and his Terra Sigillata?